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December 27, 2016 00:07

Well-differentiated adenocarcinoma of the uterus and endometrium |Symptoms and treatment of adenocarcinoma of the endometrium

A malignant tumors affecting the inner layers of the uterus called uterine adenocarcinoma of the body, thus, if the pathological cell tumors is not significantly different in structure from the cells of the affected organ, such as a one-time high-grade lesion indicate uterine adenocarcinoma.

most severe cases, doctors believe defeat the spread of the tumor in the deeper layers of tissue.This tumor may indicate too late when it is already impossible to help the woman, and this makes it difficult to diagnose itself.

When ascertaining highly differentiated adenocarcinoma of the uterus observed insignificant changes in pathological cells.It is not much different from normal: only its size increased, elongated nucleus.

danger of the disease is manifested in its garmonozavisimosti.the disease is most often diagnosed in women aged 50 - 65 years of age during menopause (menopause).This aggressive cancer cells and rapidly enough to begin to penetrate into the surrounding tissues and organs.If the tumor and

its metastases are differentiated only within the uterus itself (the first stage of the disease), surgery is performed to remove the appendage with the body of the uterus.In the case of metastatic lesions of all layers of the uterus (the second stage of the disease), the removal shall be also located close to the nodes of the lymphatic system.

-differentiated endometrial adenocarcinoma

cancerous uterine body damage is not as plentiful as, for example, malignant tumors of the cervix.This is because the endometrium (the inner layer of the mucosal lining of the uterus cavity and provided with a plurality of blood vessels) often affected in the pathology weight for aged women - between 45 - 65 years (menopause).

During this period begins to rebuild hormones a woman, his genital activity is reduced: no longer necessary to maintain the menstrual cycle, to ensure maturation of the egg and so on.But disruptions in hormone production are observed at a young age.Therefore categorically say that the high-grade adenocarcinoma of the endometrium (as, indeed, not only high-grade) affects mucosal layer of the uterus only "adult" women can not.

-differentiated endometrial adenocarcinoma - the most common type of malignant tumor of the uterus body, progressing through the glandular epithelium.This pathology is characterized by bland polymorphism cells.

affected cells of the glandular epithelium, having multiple ripening stage, as close to "normal" cell, even partially taking over its physiological functions.

high level of differentiation of cancerous tumors gives a good prognosis for recovery, in contrast to the low-grade disease.However, it is worth noting that the histological and cytological studies highly differentiated adenocarcinoma compared with the results of the analysis of other disease - atypical hyperplasia.Carry out correct diagnosis is only capable of a high level of specialist.

highly differentiated endometrioid adenocarcinoma

cancers mutate tubular glands or stratified epithelium psevdostratifitsirovannogo.Highly differentiated endometrioid adenocarcinoma frequently develop on the basis of endometrial hyperplasia, the impetus for regeneration can become estrogen stimulation of the female organism.

Tumor pathology of the variety typically have small size and presented cells are not significantly different from the norm.The cell has a larger size and in the center is a large ovoid nucleus.This pathology reveals immunopositive to intermediate filament protein of the connective tissue, as well as other tissues, have mesodermal origin.

Risk factors include:

  • Obesity.
  • delayed or late menopause.
  • Infertility.
  • diabetes.
  • Long-term use of hormonal drugs, which are based on estrogen.
  • tamoxifen - an estrogen antagonist (used in the treatment of breast cancer).
  • Uncontrolled use of oral contraceptives.

Treatment of high-grade adenocarcinoma of the uterine

Intrigue virtually all malignancies that when they begin to show its symptoms are usually observed for late-stage disease.This is the period when the tumor sprouted metastases adjacent organs and she is on the stage of decomposition, toxin poisoning the entire body of the patient.But if, during routine inspection gynecologist, a suspicion of this pathology and the disease has been diagnosed, oncologists set the degree of damage the body.

If the tumor is localized in the body of the uterus, and did not affect the surrounding tissue, the treatment of high-grade adenocarcinoma of the uterus is the most uterine resection and appendages.If the shock has already undergone all the body of the uterus, the surgeon has to remove together with the female body, and is located near the lymph nodes.Since hitting a high probability of cancer cells in the lymphatic system with their further spread throughout the body.

In severe the patient's condition and the impossibility of surgical treatment of uterine highly differentiated adenocarcinoma is conducted with the active use of hormone therapy, radiation and radiotherapy.In the case of recurrent relapses have to enter polychemotherapy.

If overt neoplastic processes are observed in order to avoid "hidden" metastasis patient passes adjuvant chemotherapy (conducted primarily after surgery).To give an opportunity to make sparing surgery, allowing to fully preserve the operated organs, or at least to minimize the surgical damage, before surgery is performed neoadjuvant chemotherapy.It also provides an opportunity to assess the sensitivity of tumors to chemotherapy drugs.When

chemotherapeutic treatment of highly differentiated adenocarcinoma of the uterus used drugs cisplatin, doxorubicin, epirubicin, paclitaxel, carboplatin and other AUC5.treatment protocol is usually represented by a complex of several mutually drugs.

Epirubicin.The drug is injected slowly, over three - five minutes into the vein.Grown isotonic sodium chloride solution.In monotherapy, receiving the dose is 60 - 90 mg per m2 (patient's body surface).The dosage may be divided into two - three days.Receiving repeated after three weeks.

In the case of dysfunction hematopoietic system capacity, elderly patient, or when used in conjunction with other therapies (eg, radiation), the dosage of the drug is taken at the rate of 60 -75 mg / m 2.This quantitative component of the course should not exceed 1000 mg / m2.

Paclitaxel.Dosage is especially individual.The drug is administered intravenously in three-hour or daily infusions.The amount of drug is calculated from indicators 135 - 175 mg per 1 m2 of the patient's body.The interval between injections every three weeks.

Hormonal therapy involves the use of medroxyprogesterone acetate, tamoxifen.

medroxyprogesterone acetate.Tablets are appointed inside.The daily intake of 200 - 600 mg.Estimated effect occurs within eight - ten weeks.

starting dose for intramuscular administration of the drug - 0.5 - 1 g per week.After stabilization, the dosage was reduced to 0.5 g per week.