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December 27, 2016 00:07

Hemolytic anemia associated with mechanical red cell damage shell

Hemolytic anemia associated with mechanical damage of erythrocyte membranes, occur in patients with prosthetic aortic valve due to intravascular destruction of red blood cells.Hemolysis is caused by the prosthetic device (mechanical valves) or dysfunction (okoloklapannaya regurgitation).Bioprosthesis and artificial valves in the mitral position rarely lead to significant hemolysis.Mechanical hemolysis is also observed in patients with synthetic arterial shunts.In the study of peripheral blood smear detect shizotsity and other fragments of red blood cells (these signs of mechanical hemolysis are present, although to a lesser degree, with normally functioning prostheses).Elevated plasma free hemoglobin, haptoglobin reduced or not detected in urine usually determined hemosiderin.Treatment is aimed at removing the prosthesis dysfunction.

Causes of hemolytic anemia associated with mechanical damage to the membrane of red blood cells

Kidney

Hemolytic-uremic syndrome

Thrombosis renal vein

rejection of transplanted kidneys

Radiation nephritis

Chronic renal failure

Diseases

cardiovascular system Malignant hypertension

aortic coarctation

Defeats valvular

Subacute bacterial endocarditis of the aortic

valve

bioprosthesis

liver disease

crushing defeat hepatocytes

Infections

Disseminated herpes infection

Meningococcal sepsis

Malaria

Other

Thrombotic thrombocytopenic purpura

DIC any etiology

Severe burns

giant hemangioma

metastasis

Medicines (mitomycin C, cyclosporine)

microangiopathic haemolytic anemia - another syndrome mechanical intravascular hemolysis, apparently due to the deposition of fibrin in small vessels.The disease occurs when the disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, severe arterial hypertension, vasculitis, eclampsia, some disseminated tumors.In peripheral blood smears revealed fragmented erythrocytes (helmet cells shizotsity), as well as thrombocytopenia.Treatment is aimed at relief of the primary pathological process.