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December 26, 2016 00:01

Limfofollikulyarnaya hyperplasia : Causes, Symptoms , Diagnosis, Treatment

Hyperplasia is a pathologic process of cell proliferation.Limfofollikulyarnaya hyperplasia - increase in the follicular tissue mucosal / submucosal layer.The disease occurs in patients of all age categories without reference to sex, food preferences and regardless of the place of residence.

Diagnosed limfofollikulyarnaya endocrine hyperplasia in the area, but most commonly affects the digestive system.The prevalence of disease caused by the gastro-intestinal tract?Of course, the number of predisposing factors - diseases of the digestive system in the chronic stage, the consumption of a large number of carcinogens, zastresovannosti level.Hyperplastic changes in endocrine organs are revealed on the background of endocrine or systemic disorders.For example, limfofollikulyarnoe defeat thymus is observed in existing pituitary pathology.

reasons limfofollikulyarnoy hyperplasia

emergence of hyperplasia is associated with a variety of negative effects on the tissue, leading to an increase in the number o

f cells.Start causative mechanism may be associated problems - obesity, abnormal liver function, hyperglycemia, etc.Hereditary factors experts also referred to the risk factor.

are the following reasons limfofollikulyarnoy hyperplasia:

  • endocrine dysfunction of the gastric mucosa;
  • hormonal abnormalities;
  • malfunction of the nervous regulation of the digestive tract;
  • deleterious effects of carcinogens, activating the abnormal cell division;
  • effects of tissue-specific degradation products;
  • blastomogenic influence;
  • presence of chronic, autoimmune, atrophic diseases of the digestive system (gastritis often form data);
  • the presence of the bacteria Helicobacter pylori;
  • permanent nervous disorders and stress;
  • herpesvirus infections;
  • dysmotility of the stomach and intestine 12-n;
  • pathology of immune character.

Symptoms limfofollikulyarnoy hyperplasia

Manifestations sickness symptoms largely depend on the localization of the foci.Generalized symptoms are considered - the temperature rise, a sense of weakness, a quantitative increase in lymphocytes and a decrease in albumin levels.It should be noted that it is often at the benign nature of the lesion symptoms limfofollikulyarnoy hyperplasia absent.Negative symptoms are common in advanced and particularly difficult cases, hyperplastic lesions of the gastrointestinal tract, which are peculiar pain abdomen (often epigastric) in the presence of dyspeptic disorders.

stages of hyperplasia are classified according to the size and distribution of the follicles:

  • zero - lymphoid follicles are absent or mild, are small and chaotic situation;
  • first - diffuse, single proliferation of small follicles;
  • second - a dense, diffuse distribution without merging into conglomerates;
  • third - crowding follicles sometimes in large colonies, they may be hyperemic mucosa;
  • fourth - erosive areas, expressed hyperemia mucosa with the presence of fibrin plaque mucosa matte color, increased vascular pattern observed.

Based on the above characteristics of the formation and course of disease, we can conclude:

  • limfofollikulyarnaya hyperplasia of the gastrointestinal tract provides the clinical manifestations of only 3-4 stage as intestinal bleeding, pain of varying intensity of the abdomen;
  • detection of the disease in other cases is a random event, as there is no specific symptoms.

Limfofollikulyarnaya hyperplasia of the gastric mucosa

complex structure of the gastric mucosa caused by performing a variety of functions, including the secretory activity, protection and participation in the process of peristalsis.Healthy mucous - is the key to proper operation of the entire digestive system.

Excessive proliferation of epithelial cells with simultaneous thickening of the walls of mucous called limfofollikulyarnaya hyperplasia of the gastric mucosa.Pathology is often accompanied by the formation of nodules or polyps.The cause of the disease are considered to be neurological and hormonal changes.Limfofollikulyarnaya hyperplasia is rarely transformed into oncology.The appearance of the cancer cells in most cases contributes to epithelial dysplasia, in which healthy cells grow into the mucous layer cells with marked atypical structure.The most dangerous is the mucous metaplasia characterized by digestive dysfunction and more likely to develop a malignant tumor type.

diagnosis and appropriate treatment - is the main problem gastroenterologist.Moreover, therapeutic methods are selected individually for each pathology.

Limfofollikulyarnaya hyperplasia of the antrum

According to statistics reason for the defeat antral region of the stomach in the presence of chronic gastritis is caused not only a response to inflammation (microorganism causative agent in this case is the Helicobacter pylori), but is a consequence ofweakening immunity.Immune changes in conjunction with gastritis, as practice shows, are identified on the condition of low acidity, which in turn is a prerequisite for the emergence of autoimmune diseases.

study of pathology in childhood led to the conclusion that limfofollikulyarnaya hyperplasia of the antrum is the consequence of an autoimmune rheumatic disease, and not the action of bacteria.Of course, the presence of pathogens and autoimmune abnormalities at times increases the risk of hyperplasia.

mucosal changes often entail occurrence of polyps, which are localized in the antrum is about 60% of all cases of gastric lesions.Polyps inflammatory nature, in other words hyperplastic occur with a frequency of 70 to 90%, of the developing mucosal or submucosal layer.It is a rounded, cylindrical shape, dense formations with a wide base and a flat top.

Limfofollikulyarnaya hyperplasia ileum

lower part of the small intestine called the ileum, lined inside with lots of mucous villi.The surface is provided with lymphatic vessels and capillaries involved in the assimilation of nutrients and minerals.Since fats are absorbed by the lymphatic sinus, and amino acids are absorbed by the bloodstream sugar.Mucosa and submucosal layers of the ileum presented circular folds.In addition to the absorption of necessary substances, the body produces special enzymes and digest food.

Limfofollikulyarnaya hyperplasia of the terminal ileum is formed as a consequence of immunodeficiency and proliferative processes of the intestinal wall.Violations found during a specific reaction to external stimulation of lymphoid tissue intestine.Clinical manifestations of a pathological condition:

  • diarrhea (frequent urge to 7 times per day);
  • inclusion of mucus / blood in the stool;
  • abdominal pain character;
  • sharp decline in body weight;
  • flatulence, bloating, and rumbling in the stomach;
  • a marked decrease in the body's defenses.

Differentiate disease allow blood, urine, feces, and the survey through fiberoptic endoscopy.Typically, purely limfofollikulyarnaya hyperplasia diagnosed in the terminal zone of the ileum, indicating that the secondary pathological process and need not be therapeutically treated.As a therapeutic and preventive measures can be recommended strict diet with limited number of foods.If we are talking about a serious inflammation, cancer or suspected Crohn's disease, the treatment is applied medication or surgery.

Diagnostics limfofollikulyarnoy hyperplasia

complexity of early detection of abnormal mucosa condition is asymptomatic disease in the early stages of formation.Often the detection of lymphoid follicles occur randomly during kolonoileoskopii for other indications.Unfortunately, the treatment of patients begin with the appearance of gastrointestinal bleeding or abdominal pain unbearable, which corresponds to the last stage of the disease.

Increased mucus layer in the stomach and intestine can be examined by endoscopic techniques, which include - colonoscopy, sigmoidoscopy and EGD.Diagnosis limfofollikulyarnoy hyperplasia is also done by using X-ray contrast agents.X-ray study helps to assess the extent of newly formed cells and endoscopic study provides a biological material for histology.Confirmation of the diagnosis

limfofollikulyarnaya hyperplasia talks about the need to constantly monitor the status in mind the possibility of the abnormal areas in malignant tumors.

Treatment limfofollikulyarnoy hyperplasia

Limfofollikulyarnaya mucosal hyperplasia, flowing with clear signs of a pathological process, is treated by reducing the acidity of the stomach and suppress the activity of helicobacter.Therapeutic scheme of suppression of H. pylori flora with compulsory elimination of gastritis takes two weeks, includes receiving medication (including antibiotics), and dieting.

presence of malignant tissue necessitates surgery.Hyperplasia of the digestive system may require resection of the stomach or bowel resection site.rehabilitation period depends on the severity of the disease, the success of the operation and the patient's general condition.The important point after surgical manipulation remains constant supervision to avoid relapses and complications.

Identification of the pathological focus in the endocrine or hematopoietic system with signs of malignancy requires prolonged combined treatment combining chemotherapy and surgical techniques impact.

Treatment limfofollikulyarnoy hyperplasia benign nature, is usually not carried out.

Prevention limfofollikulyarnoy hyperplasia

Given the fact that limfofollikulyarnaya hyperplasia in most cases are asymptomatic, reveal pathology at the stage of origin can only be through regular surveys.Therefore, regular visits to a medical institution for the purpose of passing the checkup is a must.

Prevention limfofollikulyarnoy hyperplasia includes general recommendations: a healthy and balanced diet, adherence of the day, moderate physical activity, availability of time for rest and relaxation, minimizing stress, giving up addiction to tobacco / alcohol / drugs.

It should be noted that fans engage in self-medication or folk remedies are at risk, as is symptomatic hyperplasia occurs only in the later stages of formation of the pathology.Processes, difficult to treat, develop into chronic forms of disease, require complex surgical procedures, able to transform into malignant neoplasms.

forecast limfofollikulyarnoy hyperplasia

number of patients with chronic diseases of the digestive system is steadily increasing.Such diseases are increasingly detected in childhood, leading to serious consequences and even disability.Presence in the gastrointestinal tract associated with the development of helicobacter autoimmune gastritis, which is in turn triggered by a herpes virus.How, for example, mononucleosis, is caused by infection with Epstein-Barr virus, there is a lesion of the epithelium of the digestive system with obvious signs limfofollikulyarnoy hyperplasia.

for quality treatment of autoimmune gastritis chronic course the determining factor is early diagnosis.Gastritis is an autoimmune type doatroficheskuyu shape corresponding immune response, provoking limfofollikulyarnuyu hyperplasia.

forecast limfofollikulyarnoy hyperplasia is better than before the disease is detected.By a complex therapy, including treatment regimen of chronic gastritis (a combination of interferon and immunocorrection valacyclovir), cropped pathological focus of the gastric mucosa, and normalize the body's defenses and achieve stable remission.

limfofollikulyarnaya hyperplasia diagnosis must be confirmed by clinical, morphological, endoscopic, immunological and virological data.Only after these studies may have a high-quality and effective treatment.