Advices for Life


September 21, 2016 23:06

Beta - hydroxy -beta - methyl butyrate ( HMB )

main functions

  • Increases muscle mass.
  • Reduces the amount of adipose tissue.
  • Increases strength and power.

Theoretical Foundations

Beta-hydroxy-beta-methyl butyrate (HMB) - a metabolite of Leucine - branched chain amino acids.Nissen et ai.It suggests that HMB is responsible for the well-known anti-catabolic actions ley din.HMB can partially prevent proteolysis and / or muscle damage caused by the load, and thus contribute to the growth of muscle mass and strength during training sessions to overcome resistance.

Nissen et al.It suggested that HMB is a precursor of beta-hydroxy-beta-methylglutaryl-CoA (CoA-HMB) participating in the synthesis of cholesterol by muscle cells.They believe that muscle cells can not effectively use the blood cholesterol, and must produce it themselves.In stressful situations, the muscle cells require more cholesterol for the synthesis of new cell membranes or regeneration of damaged membranes of existing cells.Thus, HMB can be important during periods of stress, suc

h as when performing the exercise with resistance to overcome, to strengthen the integrity and improve the functions of muscle cells.To confirm this theory, and clarify the mechanism of action of HMB further research is needed.

research results

data on the reduction of muscle proteolysis and increase muscle mass and strength are confirmed only two studies (published) employees at the same time the University of Iowa.The first study involved 41 untrained men (age 19-29 years, mean body weight - 82.7 kg).Subjects were randomly divided into three groups which were given various amounts of HMB -O g (placebo), 1.5 g or 3.0 g per day.In addition, they also gave one of the two protein servings of either normal - 117 grams per day (1.4 g-kg1 or overcharge - 175 grams per day (2.1 g-kg1)).Subjects lift weights for 1.5 hours 3 times a week for 3 weeks.

subjects receiving supplements HMB, showed an increase in body weight, corresponding to a dose of 0.4 kg - for the placebo group;0.8 kg - for the group treated with 1.5 g HMB and 1.2 kg - for the group, which took 3.0 grams of HMB.The level of protein consumed had no effect on body weight change quantity or weight lifted.But the subjects who received KLH-to-additive, lift loads greater than accepted within 3 weeks of placebo.The group receiving HMB-additive performed significantly more (50%) of exercises for the abdominal muscles, compared with the group, which received placebo (14%).The total strength (upper and lower body) has increased significantly in both groups: in the group with 1.5 g HMB - 13%, in the group with 3.0 g HMB - by 18.4%;this value was 8% in the placebo group.When receiving HMB muscle strength of the lower body more than the upper part.

When B Drinking GM reduced muscle damage.Urine 3-methylhistidine (3-MG) decreased by 20%, serum creatine phosphokinase muscle activity (FCMC) and lactate dehydrogenase (LDH) decreased by 20-60%.

The second study examined the effect of HMB-additives on changes in body composition and muscle strength over a longer period of 32 trained men (age 19-22 years, mean weight 99.9 kg) were randomly divided into two groups.One received a placebo, another 3.0 g of HMB per day.Subjects raised load for 2-3 hours each day, 6 days a week for 7 weeks.On the 14th day, and up to the 39th day in the subjects treated with HMB supplements significantly increased lean mass compared to those who took a placebo.On the last day of the study lean mass had no significant differences between groups.


Athletes should not consider GMB wand.Two studies were conducted the same research group that developed the GMB.The research results are of interest, but first they must be seriously analyzed.

Before using the GMS-additives, the following issues need to be addressed.

  • results have not been replicated by other researchers in other laboratories.
  • The subjects of the first study Nissen et al.They were untrained, so the results can not be applied to people trained or elite athletes.
  • three weeks of application HMB supplementation untrained subjects increased their muscle mass by comparison with the group consumed a placebo, significantly.
  • Seven weeks of HMB supplementation trained subjects did not increase their muscle mass compared to the group consumed a placebo.