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November 28, 2016 00:11

Antibodies to streptococcus A, B, C, D, F, G in blood

Infections caused by Streptococcus A, B, C, D, F, G. Antibodies to streptococcus A, B, C, D, F, G in serum titer

Streptococcus antibodies in normal serum is 12-166 units.

Streptococci are among the most common pathogens of bacterial infections in humans.On the basis of antigenic differences most of streptococci isolated from human, belongs to the group A, B, C, D, F, G.

Group A streptococci are extremely important, because often cause infectious disease in humans and play a significant role in the development ofrheumatic fever and glomerulonephritis.

Group B streptococci frequently colonize the female genital tract and mucous membranes of the throat and rectum.

Streptococci of groups C and G belong to commensals, but in some cases they can cause pharyngitis.

Group D Streptococci are often the cause of urinary tract infections in patients with structural abnormalities and more than 10% of cases - the etiological factor of bacterial endocarditis.

main method for diagnosis of streptococcal in

fection - bacteriological.Recently developed slide rapid tests (the answer can be obtained within 10 min) based immunoassay method (sensitivity - 97%, specificity - 95%), allowing to identify the antigen .beta.-hemolytic streptococcus group A in swabs from the nasopharynx and .beta.-hemolyticStreptococcus group B - in the discharge from the vagina.Serological diagnosis is based on detection of antibody titers to the polysaccharide group A streptococcus by ELISA, and the ASO in the patient's serum.

antibodies to a polysaccharide of group A streptococcus (group-specific polysaccharide - anti-A-CHO) appear in the first week of infection, their titer increases rapidly, reaching a peak in the 3-4th week of disease.Diagnostic consider an increase in antibody titer in 10-14 days at least 4 times in the study of paired sera.It should be borne in mind that even active streptococcal infection causes an increase in antibody titer in four times in only 70-80% of patients.The test for antibodies to the group A streptococcus polysaccharide normally used as an addition to the identification and ASO DNase B antibody in patients with rheumatic fever.There is a high correlation between the specific content of a permanent anti-A-CHO serum and activity of rheumatic carditis.With effective treatment, the content of anti-A-CHO is reduced by a few months later than other markers of streptococcal infection.

for diagnosis of streptococcal infection caused by streptococci other groups using the ELISA method to detect specific antibodies to the bacteria wall carbohydrates, mostly groups C and G. However, these studies are not widely known.

titer of antibodies to streptococci in various diseases

Diseases

titer AT ED

active rheumatic fever

500-5000

inactive rheumatic fever

12-250

Rheumatoid arthritis

12-250

Acute glomerulonephritis

500-5000

Streptococcal infection of the upper respiratory tract

100-333

Collagen

12-250

Determination of antibodies to streptococci are used for the diagnosis of streptococcal infection in the following diseases:

  • catarrhal, lacunar,tonsillitis;
  • erysipelas, scarlet fever, glomerulonephritis, rheumatic fever;
  • septic conditions;
  • chronic inflammatory lung disease.