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November 28, 2016 00:11

Aspartate aminotransferase ( AST ) in blood : Causes increase and decrease values

aspartate aminotransferase (AST) levels - is unpronounceable phrase refers to a particular cell enzyme that actively participates in the normal exchange and cooperation of almost all amino acids.AST is in large quantities in cardiac tissues and in the liver cells, nervous tissue and kidney.For this reason, almost all the diseases associated with these authorities, implies a certain level of aspartate aminotransferase in the blood.Aspartate aminotransferase (AST) in the blood is also a type of enzymes, for carrying aspartic acid molecules.We can say that coenzyme analogs AST is a well-known vitamin B6.

Reference quantity (rate) AST activity in serum - 10-30 IU / L.

norm is considered fairly low levels of the enzyme, but if the fabric is damaged, aspartate aminotransferase (AST) is gradually increased in the blood, releasing from the damaged cells.How seriously damaged tissue, so increased levels of AST in the blood.If myocardial infarction is diagnosed, aspartate aminotransferase begins to accumulate

in the blood stream for 6-10 hours.

aspartate aminotransferase (AST) levels may exceed the limit of normal at times to five times, and to keep such figures up to a week.The high activity of transaminases - a clear indicator of the dire condition of the patient, in which an unfavorable outcome is possible.If the ACT is growing slowly but steadily, it means that the heart attack zone expands.Also AST activity may be due to necrotic phenomena in the liver.

Why determine aspartate aminotransferase in the blood?

This analysis is important and necessary to clarify the possible diseases and pathologies such as:

  • All types of hepatitis and necrotic liver disease;
  • Rebirth parenchymal tissue in fibrotic - cirrhosis (alcoholism);
  • onkoprotsessa in liver metastases;
  • emergency cardiac condition - myocardial infarction;
  • Autoimmune, including hereditary diseases - DMD-Becker;
  • Viral lesions of the lymphatic system, including mononucleosis;
  • cholestatic syndrome.

How to prepare for the study, as verified by AST in the blood?

Acceptance of any medications, sometimes even herbal decoction, can distort the results of the study.Therefore, before checking the level and activity of AST, you should either stop taking the medication, and if this is not possible, for whatever reason, to communicate information about the drug, its dosage and time of admission to the doctor.Even a simple and harmless at first glance, valerian extract or vitamins such as vitamin A, can negate the accuracy and informativeness of research.Also, consider the allergic reactions to specific drugs, women distort the laboratory tests on AST may pregnancy.

how to analyze, how to determine the aspartate aminotransferase (AST) in the blood?Material for analysis is only deoxygenated blood.Furthermore harness pressure, light tingling at the site of the puncture needle, no pain no - this is the usual analysis, the results of which have been known for 6-12 hours.

aspartate aminotransferase in the blood - what are the rules?

normal ranges:

  • women - from 10 to 36-minute units / l;
  • men - from 14 to 20 units / liter.

too elevated AST - a liver pathology or perhaps viral nature or hepatic response to acute intoxication due to alcohol intake may narcotic drugs.Also, the high value of transaminases AST can talk about large or multiple tumors.

slight excess of the normal range - a chronic dependence on alcohol, possibly cirrhosis.Also, a small increase in aspartate aminotransferase can be at hypervitaminosis - vitamin A. Myocardial, mononucleosis, a disease of the pulmonary system or kidneys - the list goes on.The main thing to remember: aspartate aminotransferase (AST) levels - an important indicator of the state of human organs tissues and analyzes decoding - is the work of a doctor.

reasons AST increase blood

Increased AST activity in the blood was observed with a number of diseases, especially in lesions of organs and tissues that are rich in this enzyme.The most dramatic change in AST activity occur in the defeat of the heart muscle.The enzyme activity in 93-98% of patients with myocardial infarction is increased.

Myocardial infarction is increased in serum AST 6-8 hours, maximum activity is reached after 24-36 hours, and decreased to normal levels to the 5-6 th day.Enhanced myocardial infarction area leads to increased activity of the second cycle.The degree of elevation of AST reflects myocardial mass involved in the pathological process.Sometimes AST activity increases before the appearance of electrocardiographic signs of myocardial infarction, and no reduction in its level after a 3-4 day illness prognostically unfavorable.Myocardial infarction activity of AST in the blood can be increased 2-20 times.

Angina AST activity usually remains within normal limits.However, some authors indicate increased AST in severe coronary artery disease in the first 24 hours after the attack, and the normalization of the 2nd, at least the 3rd day after the attack, as well as during long bouts of paroxysmal tachycardia.

AST is also increased in acute hepatitis and other severe lesions of hepatocytes.A moderate increase was observed when obstructive jaundice in patients with metastases to the liver and cirrhosis.Coefficient de Rytis, ie the ratio of AST / ALT, normally equal to 1.33, in liver disease below this value, and in diseases of the heart - above.

number of indicators represents the factors that are multiplied by the value of the upper reference limit for AST.

In clinical practice is widely used in the simultaneous determination of blood activity of AST and ALT;it brings a lot more clinical information about the location and depth of defeat, the activity of the pathological process;It allows to predict the outcome of the disease.