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November 25, 2016 00:09

Angioedema |Symptoms and treatment of angioedema

Angioedema - a swelling of the deeper layers of the dermis and subcutaneous tissue.It can be caused by drugs, poison (particularly animal origin), or food allergens ekstraktirovannymi.The main symptom - a diffuse, painful swelling, sometimes limited.Diagnosis is based on the general survey.Treatment is aimed at the elimination or abolition of the allergen and the appointment of H2 blockers.

reasons angioedema

acute angioedema is almost anaphylactic reaction subcutaneous tissues.Sometimes it is accompanied by urticarial rash (localized erythema and blisters on the skin);in both cases, similar reasons (e.g., drugs, toxins, food allergens, and extracted).Anginevrotichesky swelling pathogenesis associated with hives, which manifests itself at the level of the dermal-epidermal connection.

Chronic (& gt; 6 weeks), angioneurotic edema, in rare cases is the lgE-mediated, often - difficult to explain a violation.The cause is usually unknown (idiopathic edema), but sometimes the cause is chronic use is not s

erious drugs or other synthetic products (penicillin in milk, non-prescription medicines, preservatives and other food additives).In some cases angioedema is innate.

symptoms of angioedema

If angioedema can be observed (or absent) light itching.This condition is characterized by a limited diffuse and painful swelling of the soft tissues, which may be asymmetric;particularly prone to edema of the eyelids, lips, face, tongue and back of your hands and feet, genitalia.Swelling of the upper respiratory tract can cause respiratory distress, stridor and sometimes mistaken for asthma.There may be a complete airway obstruction.

Diagnostics angioedema

reason is often obvious, and diagnostic tests are rare, as the reactions are stopped independently and do not recur.No tests are not particularly necessary for the diagnosis.Erythropoietic protoporphyria can masquerade as allergic form of angioedema, and is diagnosed by measuring the amount of porphyrins in the blood and feces.

Treatment of angioedema

In the case of acute angioedema treatment is the elimination or avoidance of the allergen and the appointment of symptomatic drugs (eg, H2 blockers).In the most severe cases, prednisone 30-40 mg once a day.Local therapy with glucocorticoids is useless.If the cause is not obvious, it is necessary to stop taking all secondary products.Edema of the larynx or pharynx ephedrine administered in solution 0.3 ml of 1: 1000 subcutaneously.The treatment may be supplemented with intravenous administration of antihistamines (difengidamin 50-100 mg).Long-term treatment may include the appointment of H1 - and H2-blockers and sometimes corticosteroids.

H1-blockers, oral

drug

dosage for adults

dosage for children

Available Dosage Forms

azatadine maleate

1-2 mg 2 times a day

& gt;12 years: in

adult dosage of 1 mg Tablets

brompheniramine maleate

4 mg every 4-6 hours or 8 mg every 8-12 hours

6-12 years: 2-4 mg every 6-8 hours (maximum dose of 12-16 mg a day).

& gt;12 years: the adult dosage

Tablets 4, 8, 12 mg.

Elixir 2 mg / 5 ml.

Tablets 8.12 mg (long-acting)

Chlorpheniramine maleate

2-4 mg every 4-6 h

6-11 years: 2 mg every 4-6 hours (maximum dose of 12-16mg / day).

& gt;12 years: the adult dosage

Chewable Tablets 2mg.Tablets

4, 8, 12 mg.2

Syrup mg / 5 ml.

8 Tablets or capsules, 12mg

Clemastine fumarate

from 1.34 mg 2 times per day to 2.68 mg 3 times a day

6-12 years: 05 mg every 12 hours (maximum dose of 3 g m / day) 3

Tablets 1.34;2.68 mg.

Syrup 0.67 mg / 5 ml

Cyproheptadine HCI

4 mg 3 or 4 times a day [maximum dose of 0.5 mg / (kghden)]

2-6 years: 2 mg 2 or 3 times a day (maximum 12 mg / day).

7-14 years: 4 mg 2 or 3 times a day (maximum 16mg / day)

Tablets 4 mg.

Syrup 2 mg / 5 ml

Dexchlorpheniramine maleate

2 mg every 4-6 h

2-5 years: 0,5 mg every 4-6 hours (maximum dose of 3 mg / day).

6-11 years: 1 mg every 4-6 hours (maximum dose of 6 mg / day)

2 mg tablets.2

Syrup mg / 5 ml.

Tablets 4.6 mg.(Long-acting)

Diphenhydramine

25-50 mg every 4-6 hours

1,25 m g / kg every 6 hours (maximum dose of 300 mg / day)

capsules or tablets 25, 50 mg.

Syrup 12.5 mg / ml.Elixir 12.5 / 5 ml

diphenylpyraline

5 mg every 12 hours

Data not

Capsules 5 mg (long-acting)

Hydroxyzine HCI

25-50 mg 3 or 4 times a day

0,7 mg / kg 3 times a day

Capsules 25 mg 50,100.Tablets 10,25,50 and 100 mg.10 Syrup mg / 5 ml.The oral suspension 25 mg / 5 ml

methdilazine HCI

8 mg every

& gt;3 years: 4 mg every

8 mg tablets.4 mg chewable tablets.The syrup 4 mg / 5 ml

Promethazine HCI

12,5-25 mg 2 times a day

2 years: 6,25-12,5 mg 2 or 3 timesday

12.5 tablets;25; 50 mg.Syrup 6.25 and 25 mg / 5 ml

trimeprazine tartrate

2,5 mg 4 times

6 months-3 years: 1.25 mg at night or 3 times a day.& Gt;3 years: 2.5 mg at night or 3 times a day

2.5 mg Tablets.Syrup 2.5 mg / 5 ml.Capsules 5 mg (long-acting)

tripelennamine citrate

25-50 mg every 4-6 hours

1,9 mg / kg 4 times a day (maximum 450 mg / day)

Elixir of 37.5 mg / 5 mL (1 mL citrate = 5 mg salt HCI)

tripelennamine HCI

25-50 mg every 4-6 hours

1,25

Tablets 25 mg / kg 4 times a day (maximum 300 mg / day);50 mg.Tablets 100mg (long-acting)

Triprolidine HCI

2,5 mg every 4-6 hours (maximum 10 mg / day)

4 months - 2 years: 0.313 mg every 4-6h (maxi mally
1.25 mg / day).
2-4 years: 0,625 mg every 4-6 hours (maximum
2,5 mg / day).

4-6 years: 0,938 mg every 4-6 hours (maximum 3,744 mg / day).6-12 years: 1.25 mg every 4-6 hours (maximum of 5 mg / day)

Tablets 2.5 mg.Syrup 1.25 mg / 5 ml

Without sedation

drug

dosage for adults

dosage for children

Available Dosage Forms

acrivastine

8 mg 2 or 3 times

12 years: adult dosage

capsules 8 mg

Cetirizine

5-101 mg once

& gt;12 years: the adult dosage

Tablets 5.10 mg

desloratadine

5 mg 1 time per day

& gt;12 years: the adult dosage

Tablets 5 mg

ebastine

10-20 mg 1 time a day

6-12 years: 5 mg.12-17 years: 5-20 mg 1 time per day

Tablets 10 mg

Fexofenadine

60 mg 2 times a day or 180 mg 1 time per day

6-11 years old: 30 mg 2 times a day.

12 years: adult dosage

Tablets 60.180 mg

Levocetirizine

5 mg 1 time per day

Data not

Tablets 5 mg

Loratadine

10 mg 1 time

2-5 years: 5 mg 1 time a day.

6 years of age: the adult dosage

Tablets 10 mg.Syrup 1 mg / 1 ml

mizolastine

10 mg 1 time

Data not

Tablets 10 mg

All antihistamines with sedative effect are marked anticholinergic properties.They typically are not used in the elderly and in patients with glaucoma, benign prostatic hyperplasia, delirium, dementia and ortostaticheskoi hypotension.When these drugs are marked dry mouth, decreased visual acuity, urinary retention, constipation, orthostatic hypotension.