Advices for Life

Drug Monitoring

October 07, 2016 23:03

Serum Digoxin

concentration in serum digoxin when used in therapeutic doses of 0.8-2 ng / mL (1.2-2.7 nmol / L).Toxic concentration - 2 ng / ml (more than 2.7 nmol / L). digoxin half-life period in adults is 38 hours with normal renal function, and 105 hours in anuria.achieve a state of equilibrium time of the drug in the blood - 5-7 days. Digoxin belongs to the most frequently used cardiac glycosides....

October 07, 2016 23:03

Theophylline in Serum

theophylline serum concentrations when used in therapeutic doses of 8-20 mg / l (44-111 micromol / L).Toxic concentration - 20 g / l (more than 111 mmol / l). The half-life of theophylline in adults - 3.5 hours in children - 8-9 hours, in newborns - 103 hours achieve a state of equilibrium time of the drug in the blood (multiple oral doses) for adults -. 2 days in children -1-2 days in i...

October 07, 2016 23:03

Serum Lithium

lithium concentration in the blood serum of normal 0,14-1,4 mol / l, while taking lithium in therapeutic doses - 0.8-1.3 mmol / l.Toxic concentrations - more than 2 mmol / l. lithium ions are absorbed in the gastrointestinal tract.It is excreted in the urine (95%), feces (1%) and then (5%).The concentration of lithium in the saliva significantly higher than its concentration in the blood s...

October 07, 2016 23:03

Cyclosporin blood

cyclosporin concentration in blood when used in therapeutic doses (peak concentration) of 150-400 mg / ml.Toxic concentration - 400 mg / ml. The half-life of cyclosporin -. 6-15 hours Tacrolimus is widely used as an effective immunosuppressant for the oppression of the reaction "graft versus host" after surgery for a bone marrow transplant, kidney, liver, heart, and in the treatment of c...